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Liver injury during highly pathogenic human coronavirus infections.

Identifieur interne : 000160 ( Main/Exploration ); précédent : 000159; suivant : 000161

Liver injury during highly pathogenic human coronavirus infections.

Auteurs : Ling Xu [République populaire de Chine] ; Jia Liu [République populaire de Chine] ; Mengji Lu [République populaire de Chine] ; Dongliang Yang [République populaire de Chine] ; Xin Zheng [République populaire de Chine]

Source :

RBID : pubmed:32170806

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), the pathogen of 2019 novel coronavirus disease (COVID-19), has posed a serious threat to global public health. The WHO has declared the outbreak of SARS-CoV-2 infection an international public health emergency. Lung lesions have been considered as the major damage caused by SARS-CoV-2 infection. However, liver injury has also been reported to occur during the course of the disease in severe cases. Similarly, previous studies have shown that liver damage was common in the patients infected by the other two highly pathogenic coronavirus - severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV), and associated with the severity of diseases. In this review, the characteristics and mechanism of liver injury caused by SARS-CoV, MERS-CoV as well as SARS-CoV-2 infection were summarized, which may provide help for further studies on the liver injury of COVID-19.

DOI: 10.1111/liv.14435
PubMed: 32170806


Affiliations:


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